abstract::Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial epithelial cells (BECs) with tryptase promoted gap closure, migr...
journal_title:Cell adhesion & migrationpub_type: 杂志文章
doi:10.1080/19336918.2021.1950594
更新日期:2021-12-01 00:00:00
abstract::There is a paucity of research on forensic psychiatry patients from Nunavut, including no published data concerning the prevalence and characterisation of patients in this territory. The lack of basic information hinders the evaluation of services and establishing best practices. The current paper aims to characterise...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1954362
更新日期:2021-12-01 00:00:00
abstract::Atherosclerosis (AS) is one of the main causes of cerebral infarction. Researches on AS mainly focus on the gene level, among which microRNA is the research hotspot nowadays. This study investigated the diagnostic value of aberrant serum miR-488 in AS patients, and further explored the effect of abnormally expressed m...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1953212
更新日期:2021-12-01 00:00:00
abstract::Oral squamous cell carcinoma is one of the most common malignant tumors of the head and neck. Increasing evidence suggests that various non-coding RNAs, such as circRNAs, are implicated in a myriad of biological processes supporting tumor progression. Recent studies have revealed that several circRNAs are dysregulated...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1953214
更新日期:2021-12-01 00:00:00
abstract::Extracellular vesicles (EVs) long RNAs (exLRs) have been shown to be indicators for the diagnosis and prognosis of colorectal cancer (CRC); however, the dynamic changes of exLRs during perioperative period and their cellular sources in CRC remains largely unknown. In this study, exLR sequencing (exLR-seq) was performe...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1943281
更新日期:2021-12-01 00:00:00
abstract::Uterus Corpus Endometrial cancer (UCEC) is the sixth most common malignant tumor worldwide. In this research, we identified diagnostic and prognostic biomarkers to reflect patients' immune microenvironment and prognostic. Various data of UCEC patients from the TCGA database were obtained. Firstly, patients were divide...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1947940
更新日期:2021-12-01 00:00:00
abstract::In this paper, we examine the perceptions of well-being among older South Sámi people with various experiences from reindeer herding by use of a method called photovoice. Eleven participants, including six men and five women aged 67-84 years, agreed to take photos of situations, things, or persons that made them feel ...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1936971
更新日期:2021-12-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) patients undergo infectious exacerbations whose frequency identifies a clinically meaningful phenotype. Mouse models have been mostly used to separately study both COPD and the infectious processes, but a reliable model of the COPD frequent exacerbator phenotype is still la...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1937883
更新日期:2021-12-01 00:00:00
abstract::Supported catalysts, consisting of PMo12 immobilized on silver nanomaterials at different recombination time and the silver nanomaterials with different template sodium citrate amount characterized by FT-IR, XRD, SEM, UV-vis and other test methods. The results show that the AgNPs are relatively uniformed with sizes be...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19534
更新日期:2021-12-01 00:00:00
abstract::Enhanced permeation and retention (EPR) effect, the mechanism by which nanodrugs accumulate in tumors and acquire superior curative effect. The questions of these mechanisms occur because of limited clinical transformation of engineered nanomaterials after 30 years. The difference of EPR limits the therapeutic effect ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19524
更新日期:2021-12-01 00:00:00
abstract::Noble metal nanoparticles have special properties in optical, electronic, and physical chemistry due to their high surface area and volume. With the development of electronic printing technology, inkjet printing has gradually replaced traditional spin coating and blade coating, since it leads to more material savings ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19518
更新日期:2021-12-01 00:00:00
abstract::Supercapacitor and hydrogen-based fuel cells are cheap and environmental-friendly next-generation energy storage devices that are intended to replace Lithium-ion batteries. Metal oxide nanostructures having perovskite crystal structure have been found to exhibit unique electrochemical properties owing to its unique el...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19321
更新日期:2021-12-01 00:00:00
abstract::Diosbulbin-B (DB) is a promising therapeutic drug for cancer treatment; however, DB-induced hepatotoxicity seriously limits its clinical utilization. Based on this, the present study investigated whether the Angelica sinensis extract, angelica sinensis polysaccharide (ASP), was effective to attenuate DB-induced cytoto...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950280
更新日期:2021-12-01 00:00:00
abstract::Nanotechnology has the ability to produce novel nano-sized materials with excellent physical and chemical properties to act against phytopathogenic diseases, essential for revolution of agriculture and food industry. The development of facile, reliable and eco-friendly processes for the synthesis of biologically activ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19515
更新日期:2021-12-01 00:00:00
abstract::Cancer is a leading cause of death among Inuit. A legacy of colonialism, residential schools, and systemic racism has eroded trust among Inuit and many do not receive culturally safe care. This study aimed to explore the meaning of culturally safe cancer survivorship care for Inuit, and barriers and facilitators to re...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1949843
更新日期:2021-12-01 00:00:00
abstract::This study aimed to investigate the expression, biological function, and downstream mechanism of LINC00511 in gastric cancer (GC). In paired GC samples, LINC00511, miR-625-5p and STAT3 mRNA expression levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR); STAT3 protein expression was detec...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1940611
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic has resulted in the rapid reorganisation of health and social care services. Patients are already at significant risk of healthcare-associated harm and the wholesale disruption to service delivery during the pandemic stood to heighten those risks. OBJECTIVES:We explored the type and na...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1945029
更新日期:2021-12-01 00:00:00
abstract::Background: The ageing Arctic populations raise the need for work-up of cognitive function that reflects language and cultural understandings.Aim: To translate and evaluate tools for work-up of cognitive impairment in Greenland.Methods: Step A: An expert panel was established to select tools suitable for the work-up o...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1948247
更新日期:2021-12-01 00:00:00
abstract::Candida auris has emerged as a fungal pathogen that causes nosocomial outbreaks worldwide. Diseases caused by this fungus are of concern, due to its reduced susceptibility to several antifungals. C. auris exhibits paradoxical growth (PG; defined as growth at high, but not intermediate antifungal concentrations) in the...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1927609
更新日期:2021-12-01 00:00:00
abstract::Asthma is mentioned as a chronic airway inflammatory disease, whose pathogenesis is complicated. The promotion of inflammation in asthma by IL-17A and IL-17F has been confirmed. In addition to covalent homodimers, both cytokines are also able to form heterodimers, further inducing downstream pathways via binding to th...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1940622
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:The inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established. OBJECTIVES:The study investigates the levels of C reactive protein (CRP), interleukin 1β (IL-1β) and stromal-derived factor 1α (SDF-1α) at the time of acute myoca...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1916070
更新日期:2021-12-01 00:00:00
abstract::In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a-e and 7a-i) was designed and synthesised. The anticancer activity for compounds (5b-d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lines. Compound 5d was the most efficient, and thus subjected to the five-dose...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1944127
更新日期:2021-12-01 00:00:00
abstract::Current treatments for osteoporosis and other bone degenerative diseases predominately rely on preventing further bone erosion rather than restoring bone mass, as the latter treatments can unintentionally trigger cancer development by undiscriminatingly promoting cell proliferation. One approach to circumvent this pro...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1938753
更新日期:2021-12-01 00:00:00
abstract::The objective was to evaluate the effect of concentrate supplementation using by-products of the Amazonian industry on milk production, milk composition, and milk fatty acid profile of dairy buffaloes. Twelve lactating buffaloes (544.5 ± 35.6 kg, 6.4 ± 2.2 years old, 59 ± 6 days in milk) were allotted in a pasture of ...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13576
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:The aim of current systematic review and meta-analysis is to provide insight into the therapeutic efficacy of fecal microbiota transplantation (FMT) for the decolonization of antimicrobial-resistant (AMR) bacteria from the gut. METHODS:The protocol for this Systematic Review was prospectively registered wit...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1927170
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:Multiple myeloma (MM) is a malignant disease with abnormal proliferation of clonal plasma cells. Hypoxia is an important factor in the pathogenesis and development of MM. However, the underlying mechanisms are not fully understood. MATERIAL & METHODS:To determine hub genes related to hypoxia in MM, this study ...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1943617
更新日期:2021-12-01 00:00:00
abstract::The present study aimed to investigate the brain targeting efficacy of Lamotrigine (LTG) loaded PLGA nanoparticles (LTG-PNPs) upon intranasal administration. LTG-PNPs were fabricated through the emulsification-solvent evaporation technique and evaluated for % Entrapment efficiency, particle size, in-vitro release, sur...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1939709
更新日期:2021-12-01 00:00:00
abstract::Oxidative stress has been proven to play a critical role in the pathogenesis of neuronal injury. As a novel adipocytokine, omentin is produced by visceral adipose with insulin sensitizing effects and has been revealed to possess anti-inflammatory effects. However, the possible effect of omentin on oxidative stress rem...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1892707
更新日期:2021-12-01 00:00:00
abstract::In the initial pandemic phase, effluents from wastewater treatment facilities were reported mostly free from Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) RNA, and thus conventional wastewater treatments were generally considered effective. However, there is a lack of first-hand data on i) comparative efficacy o...
journal_title:Chemical engineering journal (Lausanne, Switzerland : 1996)pub_type: 杂志文章
doi:10.1016/j.cej.2021.130635
更新日期:2021-12-01 00:00:00
abstract::Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation assays to select th...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1937145
更新日期:2021-12-01 00:00:00
abstract::Annotation of surgical video is important for establishing ground truth in surgical data science endeavors that involve computer vision. With the growth of the field over the last decade, several challenges have been identified in annotating spatial, temporal, and clinical elements of surgical video as well as challen...
journal_title:Computer assisted surgery (Abingdon, England)pub_type: 杂志文章
doi:10.1080/24699322.2021.1937320
更新日期:2021-12-01 00:00:00
abstract::Pancreatic cancer (PAAD) is a common malignancy with a poor survival rate. The identification of novel biomarkers could improve clinical outcomes for patients with PAAD. Here we evaluated the expression and clinical significance of PPP1CB in PAAD. PPP1CB expression was higher in PAAD tissue than in matched paracancero...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1934243
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumour of the head and neck. Our previous study reveals that the circular RNA (circRNA) hsa_circ_0042823 is abnormally expressed in LSCC, suggesting that hsa_circ_0042823 is closely associated with LSCC. Here, we attempted to explore the molecula...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1934725
更新日期:2021-12-01 00:00:00
abstract::CD123 targeting molecules have been widely applied in acute myelocytic leukemia (AML) therapeutics. Although antibodies have been more widely used as targeting molecules, aptamer have unique advantages for CD123 targeting therapy. In this study, we constructed an aptamer hydrogel termed as SSFH which could be precisel...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1934191
更新日期:2021-12-01 00:00:00
abstract::We prospectively investigated the neurological development in infants born from mothers treated with telbivudine (LdT) in the third trimester for prevention of hepatitis B virus (HBV) mother-to-infant transmission. Mothers with high HBV load were assigned to either the LdT group (n = 81, 600 mg of LdT each day from ge...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1936769
更新日期:2021-12-01 00:00:00
abstract::In recent years, genes associated with N6-methyladenosine (m6A) modification were found to participate in modulation of multiple tumor biological processes. Concomitantly, the significantly complicated dual effects of tumor microenvironment have been observed on cancer progression. The present study aims to investigat...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1937910
更新日期:2021-12-01 00:00:00
abstract::Sepsis, resulting from a harmful or damaging response to infection, is a complex and severe disease that causes high mortality. Three independent expression profiles of miRNA - GSE94717, GSE149764, and GSE101639 - were collected and integrated to analyze miRNAs associated with sepsis. One miRNA, miR-223-3p, was detect...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1935405
更新日期:2021-12-01 00:00:00
abstract::Our study seeks to obtain data which help to assess the impacts and related mechanisms of microRNA miR-509-3p in hepatocellular carcinoma (HCC). We found that the expression of miR-509-3p was down-regulated and Twist was up-regulated in HCC tissues and cell lines (HepG2, HCCLM3, Bel7402, and SMMC7721) compared with th...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1932210
更新日期:2021-12-01 00:00:00
abstract::The principal goal of the present investigation was to enterprise new and effective drug delivery vesicle for the sustained delivery of local anesthetic lidocaine hydrochloride (LDC), using a novel combination of copolymeric hydrogel with tetrahydroxyborate (COP-THB) to improve bioactivity and therapeutic potential. T...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1931558
更新日期:2021-12-01 00:00:00
abstract::We report 11 cases of SARS-CoV-2 infection in healthcare workers (HCW) naïve for COVID-19 and seropositive after the second dose of the BNT162b2 mRNA vaccine. Based on voluntary-based surveillance, they tested positive for different strains of SARS-CoV-2, as Spike gene sequencing showed. Five of them reported mild sym...
journal_title:Emerging microbes & infectionspub_type: 信件
doi:10.1080/22221751.2021.1942230
更新日期:2021-12-01 00:00:00